PCOSense, what is it?
PCOSense is a complete natural health solution for women with polycystic ovarian syndrowm (PCOS). It is one of the first formulas to combino myo-inositol and D-chiro-inositol at a 40:1 ratio, plus folate and vitamin B12. This formula supports normal menstrual cycle and fertility, healthy glucose balance and reduced serum testosterone in women with PCOS.
Polycystic Ovarian Syndrome also known as PCOS, is one of the most common metabolic and hormonal disorders, affecting one in ten women of reproductive age. Women with PCOS present with a variety of symptoms associated with menstrual dysfunction and androgen excess, including irregular menstrual cycles, weight gain, infertility and insulin resistance.
Insulin resistance affects 30-40% of women with PCOS and is believed to play a key role in abnormal ovarian function. Multiple clincal trials support supplementation with myo-inositol and D-chiro-inositol to help with the hormonal and metabolic symptoms of PCOS by promoting healthy glucose metabolism and reducing insulin resistance.
In a placebo-controlled, double-blind clinical trial, women with PCOS were supplemented with 4g of myo-inositol plus 400mcg of folic acid daily. After 16 weeks, women taking myo-inositol experienced an 84% increase in whole body insulin sensitivity, compared to no change in the placebo group. Myo-inositol was also shown to improve glucose tolerance and reduce serum total testosterone and serum-free testosterone concentrations by 66% and 73% respectfully. In addition, 69.5% of these women ovulated, compared to 21% taking the placebo.
In a 12-week clinical study, obese PCOS patients were supplemented with 500mg of D-chiro-inositol daily. Patients experienced significant improvements in insulin sensitivity, especially those with a faimily history of diabetes. Hormonal patterns also improved and patient body mass index (BMI) decreased.
Both myo-inositol and D-chiro-inositol have been clinically shown to support a normal menstrual cycle and oculation in women with PCOS. In another double-blind, placebo-controlled trial, PCOS patients were supplemented with 4g of myo-inositol plus 400mcg of folic acid daily. Over the 14-week study, parameters of ovarian function improved, including a 25% increase in ovulation frequency (versus a 15% increase in the placebo group) and a significantly shorter time to first ovulation (24.5 days versus 40.4 days for the placebo group).
D-chiro-inositol was shown to help reuglate the menstrual cycle in 62.5% of women with PCOS and chronic ovulatory dysfunction whne taken for at least four months at a dose of 1g per day plus 400mcg of folic acid. The prospective cohort study also found that D-chiro-inositol helped lower testosterone and luteinizing hormone levels, as well as other metabolic parameters related to PCOS.
PCOS is the most common cause of infertility due to anovulation (lack of ovulation). A meto-analysis of sevin trials found that supplementation with 4g of myo-inositol plus 400mcg of folic acid daily increased pregnancy rates amond infertile women undergoing treatments to induce ovulation, such as in vitro fertilzation (ICF). Supplementation also allowed for the reduction of ovulation medication needed to promote fetility. In addition, a clinical study supplementing 1.1g of myo-inositol plus 27.6mg of D-chiro-inositol daily helped improve oocyte and embryo quality, as well as pregnancy rates in women with PCOS undergoing IVF.
Active folate (L-5-MTHF) and methycobalamin (vitamin B12) support fertility and normal early fetal development, help form blood cells, and are factors in the maintenance of good health. Clinical studies show that folate supplementation at least three months before conception and during early pregnancy reduces the risk of neural tube birth defects by 42-87%.
The recommended adult dose is to stir one scoop (2.15g) in 250ml of water, twice daily or as directed by a health care practitioner.